Changes and clinical significance of serum homocysteine and lipids in Patients with primary hypothyroidism and hyperthyroid

Objective:To investigate the relationship of cardiovascular diease with serum homocysteine (Hcy), lipids in patients with primary hypothyroidism and hyperthyroid. Methods: Free triiodothyronine (FT3),free thyroxin (FT4), triglyceride (TG), total cholesterol (Tch), high density lipoprote in-cholesterol (HDL-C) and lowdensity lipoprote in-cholesterol (LDL-C) of 29 patients with primary hypothyroidism, 35 hyperthyroid and 30 healthy subjects were measured. The correlation were analyzed. Results: It was found that Hcy, TG, Tch, LDL-C in primary hypothyroidism were all significantly higher than that in healthy subjects (p0.01, 0.01, 0.01, 0.01), but the serum levels of HDL-C were significantly lower than that in healthy subjects (p0.01). The serum levels of Hcy had no relation with HDL-C and LDL-C, but the Hcy was negatively related with FT3 and FT4 (r=-0.432,-0.354 p0.01, 0.01)and positively related with TG,Tch (r=0.339, 0.452, p0.01,0.01). The Hcy and Tch in hyperthyroid was significantly lower than that in healthy subjects(p0.01,0.01), The Hcy was negatively positive related with FT4 (r=-0.408,p 0.01). Conclusion: The serum homocysteine maybe an assistant factor to determine thyroid function. The level of thyroidhormone affects the metabolism of serum Hcy and lipids levels, and high homocysteinemia in hypothyroidism is possible a risk factor of cardiovascular diease.