Lewis and Brönsted acid catalyzed Friedel–Crafts hydroxyalkylation of mucohalic acids: a facile synthesis of functionalized γ-aryl γ-butenolides
2007
Abstract A catalytic, green and practical method for Friedel–Crafts hydroxyalkylation of mucohalic acid has been accomplished. Reaction of mucohalic acids with various electron-rich aromatic compounds in the presence of catalytic (1 mol % to 10 mol %) In(OTf) 3 or Bronsted acid, such as H 2 SO 4 in acetic acid provides γ-aryl γ-butenolides in moderate to excellent yield.
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