Abstract A95: Therapeutic effects of standardized Wedelia chinensis extract on prostate cancer in vivo

Globally, prostate cancer is the sixth leading cause of cancer-related death in men with higher prevalence in Western countries. Signaling pathway of androgen receptor plays a central role in the prostate cancer progression. Accordingly, approaches and molecular mechanisms to ablate the androgen receptor function in prostate cancer have been actively studied to improve the disease treatment. However, the disease inevitably develops resistance to all forms of hormonal therapies. To mimic the clinical progression of human prostate cancer in mouse model, we implant human prostate cancer cell lines that were tagged with Luc2 reporter by lentivirus-mediated infection in the prostate gland of nude mouse. After tumor established, the orthotopic xenograft were treated with castration and progressed to castration-resistant prostate cancer (CRPC). While chemotherapy of the CRPC with intravenous docetaxel induced initial tumor regression, the tumors inevitably recurred with subsequent metastasis. We prepared a standardized herbal medicine from Wedelia chinensis plant with compounds that attenuate prostate cancer growth in vivo. Here, we investigated the combinational effect of the herbal remedy and docetaxel in the treatment of CRPC. In contrast to the docetaxel monotherapy, the docetaxel plus herbal remedy significantly delayed the tumor recurrence at primary site and distant sites, among which the CRPC in 27% mice was cured. The promising therapeutic effects of candidate herbal medicine against locally advanced tumor and subsequent metastases warrant further analyses for the underlying cellular and molecular mechanisms. (Supported by Academia Sinica, Career Development Award) Citation Format: Pei-Wen Hsiao Hsiao, Chin-Hsien Tsai, Yu-Chih Hsiao Yang, Ming-Ting Lee. Therapeutic effects of standardized Wedelia chinensis extract on prostate cancer in vivo. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Invasion and Metastasis; Jan 20-23, 2013; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2013;73(3 Suppl):Abstract nr A95.