Resistant Hypertension, Elevated Aldosterone/Renin Ratio and Reduced RGS2: A Pathogenetic Link Deserving Further Investigations?

Hypertension control is unsatisfactory in most countries and it carries an unacceptably high cardiovascular risk and death toll (Mancia et al., 2007) The reasons for the poor blood pressure control are different and interrelated (motivation of patients and physicians, costs, compliance, access to health care, secondary and resistant hypertension). Among them, resistant hypertension is receiving considerable attention, as it may be caused by unrecognized secondary hypertension, mainly primary aldosteronism (PA).