Non-Hodgkin's Lymphoma: Review Questions

1. A 60-year-old woman presents with new, asymptomatic left axillary lymphadenopathy. A biopsy reveals follicular lymphoma. Staging computed tomography (CT) scans show multiple mediastinal, axillary, and mesenteric lymph nodes. The largest lymph nodes are 3 cm in diameter and are not compressing surrounding organs. A bone marrow biopsy and aspirate are consistent with follicular lymphoma involvement. She otherwise feels well and has no history of night sweats, fatigue, or weight loss. What is the most appropriate management option for this patient at this time? (A) Close monitoring with repeat CT scans in 3 to 6 months (B) Combination chemotherapy and monoclonal antibody therapy (C) High-dose chemotherapy with stem cell transplantation (D) Single-agent chemotherapy (E) Total lymph node irradiation