Truxillic acid derivatives act as peroxisome proliferator-activated receptor γ activators
2010
Abstract In previous studies, we identified a truxillic acid derivative as selective activator of the peroxisome proliferator-activated receptor γ, which is a member of the nuclear receptor family and acts as ligand-activated transcription factor of genes involved in glucose metabolism. Herein we present the structure–activity relationships of 16 truxillic acid derivatives, investigated by a cell-based reporter gene assay guided by molecular docking analysis.
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