Applications of mesenchymal stem cell and genetically modified mesenchymal stem cell

The invention relates to applications of a mesenchymal stem cell and a genetically modified mesenchymal stem cell, especially relates to applications of a mesenchymal stem cell and a genetically modified mesenchymal stem cell in preparation of products for treating periodontal disease, repairing periodontal bone tissue or soft tissue defect and/or promoting regeneration of periodontal tissue. The invention further relates to a composition containing the mesenchymal stem cell and/or the genetically modified mesenchymal stem cell, and a cell patch. According to the invention, prosthodontic treatment effect of MSC (Mesenchymal Stem Cells) from different sources on the periodontal bone defect and periodontitis soft tissue is proved successfully, and a strong evidence for expanding seed cell source is provided; meanwhile, the application also proves that the prosthodontic treatment effect of MSC modified by an HGF (Hepatocyte Growth Factor) gene on periodontal bone defect and periodontitis soft tissue is superior to that of simple MSC, and shows that HGF and MSC can play a role in cooperation in prosthodontic treatment of periodontal bone tissue or soft tissue defect and/or promoting regeneration.