Flavonoids with antiplasmodial and cytotoxic activities of Macaranga triloba.

Abstract A new flavanone derivative, malaysianone A ( 1 ), four prenylated flavanones, 6-prenyl-3′-methoxyeriodictyol ( 2 ), nymphaeol B ( 3 ), nymphaeol C ( 4 ) and 6-farnesyl-3′,4′,5,7-tetrahydroxyflavanone ( 5 ), and two coumarins, 5,7-dihydroxycoumarin ( 6 ) and scopoletin ( 7 ), were isolated from the dichloromethane extract of the inflorescences of Macaranga triloba . The structures of these compounds were elucidated based on spectroscopic methods including nuclear magnetic resonance (NMR-1D and 2D), UV, IR and mass spectrometry. The cytotoxic activity of the compounds was tested against several cell lines, with 5 inhibiting very strongly the growth of HeLa and HL-60 cells (IC 50 : 1.3 μg/ml and 3.3 μg/ml, respectively). Compound 5 also showed strong antiplasmodial activity (IC 50 : 0.06 μM).