Pulmonary Arterial Hypertension in Hospitalized Patients With Polycythemia Vera (from the National Inpatient Database).

Abstract The prevalence and pathophysiology of pulmonary arterial hypertension (PAH) in myeloproliferative neoplasms (MPN) is poorly understood and have not been evaluated on larger scale studies. These reports generally focus on all MPN rather than each disease individually. We aim to establish the prevalence and association of PAH in patients with polycythemia vera (P. vera) using The Nationwide Inpatient Sample (NIS) database. We identified 38,395 patients with a discharge diagnosis of P. vera and 39,395,521 patients without P. vera. Both groups were queried for a concomitant discharge diagnosis of PAH. Unadjusted and multivariate adjusted logistic regression analyses were performed to determine if presence of P. vera predicted PAH after adjusting for clinically relevant risk factors. The prevalence of P. vera was 0.1% of all hospital discharge records. Pulmonary arterial hypertension was more prevalent in patients with P. vera as compared to the control population (7.9% vs. 1.9%, p