The impact of gender and age in renal cell carcinoma: age is an independent prognostic factor in women but not men

5091 Background: Renal cell carcinoma (RCC) occurs twice as often in men as in women; however, the influence of gender on stage, grade, subtype and survival has not been studied in detail. If this imbalance in RCC incidence was related to gender-specific hormone levels, age could be a further significant variable. Methods: This study included 5,654 patients treated by nephrectomy at 10 international academic centers. Differences in gender, age, T, N, and M stage, Fuhrman grade, and histological subtype were evaluated with chi- square and Student’s t-tests. Kaplan-Meier survival estimates and Cox proportional hazards models addressed the impact of gender and age on disease-specific survival (DSS). Results: Of the 5,654 patients, 3,777 (67%) were men and 1,877 (33%) were women. Generally, women presented at lower T stages (p<0.001), less frequently had distant metastases (p<0.001) and had lower grade tumors (p<0.001). In addition, women more frequently had clear-cell (87% vs. 82%) and less frequently had pa...