The effect of ovarian hormones on the sulphomucopolysaccharides of the uterus.

The distribution of sulphomucopolysaccharides was determined radioautographically and the distribution of acid mucopolysaccharides was determined metachromatically in the uteri of hormone-treated ovariectomized rats.The animals were autopsied 12, 90, and 204 hours after itraperitoneal treatment with sodium sulphate-S35 and a definite difference in the uptake of labelled material was noted in the uteri of the hormone-treated animals autopsied 204 hours after administration of S35. The greatest variability was observed in the endometrial stroma.Radioactive sulphur was scattered lightly throughout the stroma of the ovariectomized and ovariectomized-progesterone treated rats, while in the ovariectomized-estrogen treated animals the silver grains were extensive and localized primarily in the outer part of the stroma. In the estrogen-progesterone treated rats more grains were present than in the castrate, but less than seen following estrogen alone. The silver grains were observed over the extracellular matrix ...