Síndrome Antifosfolípido. Estudio de Serie de Casos Atendidos en el Hospital Universitario Antonio Prince Lara

El sindrome antifosfolipidico (SAF) es un estado autoinmune de hipercoagulabilidad causado por anticuerpos dirigidos contra los fosfolipidos de las membranas celulares. Objetivo: describir las caracteristicas clinico-epidemiologicas de los pacientes con diagnostico de sindrome antifosfolipidico que acudieron al hospital universitario A Prince Lara. Pacientes y Metodos: investigacion cuantitativa, descriptiva, no experimental y transversal. Se incluyeron 45 historias medicas de pacientes con diagnostico de SAF. Resultados: del total de la muestra 100% eran de sexo femenino. La media de la edad fue de 31,46 anos; 40,2% eran ama de casa, 15,6% estudiante, 13,3% de profesion secretaria, 13,3 % comerciante, Costurera 6,7%, maestra 4,4% y enfermera 4,4%. El 75,60% de los pacientes eran pacientes obstetricas y el resto provenia de la consulta de reumatologia. La forma de presentacion mas frecuente fue la de abortos recurrentes en 80% de los casos. El tipo de sindrome antifosfolipidico mas frecuente fue el primario 68,9% y mas de un tercio de los casos requirio la combinacion de tratamientos farmacologico con heparina de bajo peso molecular, warfarina o aspirina. Conclusion: El sindrome antifosfolipidico es una enfermedad con amplia gama de presentaciones clinicas, inmunologicas y epidemiologicas. Abstract CASE SERIES STUDY OF PATIENTS WITH DIAGNOSIS OF ANTIPHOSPHOLIPID SYNDROME ATTENDED AT THE ANTONIO PRINCE LARA UNIVERSITY HOSPITAL Antiphospholipid syndrome is an autoimmune state of hypercoagulability caused by antibodies directed against the phospholipids of cell membranes. Objective: To describe the clinical and epidemiological characteristics of patients with a diagnosis of APS who attended in the university hospital A Price Lara. Materials and methods: Case series quantitative, descriptive, non-experimental and transversal research. Out of a population of 4636 medical records of patients, a sample of 45 medical records of patients with diagnosis of antiphospholipid syndrome was analyzed. Results: 100% of patients were female, mean age was 31.4 years old; 40 % were housewives, 13.33% secretary and another 13.33% dealer. 75.6% of patients were obstetric patients and the rest came from the rheumatology consult. The most frequent presentation was recurrent abortions in 80% of cases. Most frequent antiphospholipid syndrome was primary (68.9%) and one third of the cases required more than one type of medical treatment with low molecular weight heparin, warfarin or aspirin. Conclusion: Antiphospholipid syndrome is a disease with a wide range of clinical, immunological and epidemiological presentations that respnds to antithrombotic medication.