Immunohistochemical telomeric-repeat binding factor-1 expression in gastrointestinal tumors.

The maintenance of telomere length has been hypothesized to be involved in the early steps of c ancero genesis. A physiologic modulation of telomere maintenance is exerted by TRF1 (telomeric-repeat binding factor- I), which deletion permits telomere elongation. Gastrointestinal neoplastic (n=19) and non-neoplastic tissues (six inflammatory disease and six normal mu cosa distant from tumor at le ast 5 cm) were studied, by immunohistochemistry, for TRF1 expression, by using a polyclonal antibody anti TRF1. Differentiated and not proliferating epithelial sec retory cells (Ki67 and p53 negative cells) were stained by anti- TRF1, which did not stain tu mor cells in all cases but one (p

Keywords:

• Molecular biology
• Gene expression
• Cancer research
• Molecular medicine
• Cell cycle
• Cell
• Telomere
• Carcinogenesis
• Biology
• Immunohistochemistry
• Oncogene

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