A FACILE METHOD FOR THE SYNTHESIS OF GLAUCINE AND NORGLAUCINE FROM BOLDINE

ABSTRACT A large-scale preparation of glaucine was achieved by reacting boldine with trimethylphenylammonium chloride and potassium t-butoxide in high yield. Treatment of glaucine with 30% H2O2, subsequent with hydrated ferrous sulfate, afforded norglaucine in an overall yield of 40%.