LC–MS quantification of oligonucleotides in biological matrices with SPE or hybridization extraction

Luc Sips,Emmanuel Njumbe Ediage,Benno Ingelse,Tom Verhaeghe,Lieve Dillen

LC–MS quantification of oligonucleotides in biological matrices with SPE or hybridization extraction

2019

Luc Sips
Emmanuel Njumbe Ediage
Benno Ingelse
Tom Verhaeghe
Lieve Dillen

Aim: Quantitative LC–MS analysis of oligonucleotides (OGNs) in biological matrices is needed to support candidate selection of new therapeutic OGNs. Methodology & results: A set of 20 single strand...

Keywords:

Chromatography
Chemistry
Liquid chromatography–mass spectrometry
Matrix (mathematics)
Oligonucleotide
single strand

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