Characteristics of infectious mononucleosis with dual infection of Epstein-Barr virus and cytomegalovirus

Objective The aim of this study was to explore the characteristics of infectious mononucleosis with dual infection of Epstein-Barr virus and cytomegalovirus.Method The characteristics of 21 children with IM infected by EBV/CMV were retrospectively analyzed and compared with the EBV infection cases.Results ① Clinical manifestations:the duration of fever was significantly higher in the EBV/CMV dual infection group than that in the EBV infection group (P ＜ 0.05).The incidence of hepatomegaly and splenomegaly were significantly higher in the dual infection group than that in the EBV infection group (P ＜ 0.05 or P ＜ 0.01).A significantly higher frequency of complicating thrombocytopenia,pneumonia and anemia were observed in the EBV/CMV dual infection group than in the EBV infection group (P ＜ 0.01).②Laboratory findings:the rate of atypical lymphocyte and the incidence of abnormal liver function were significantly higher in the dual infection group than that in the EBV infection group (P ＜ 0.01).Conclusion The IM cases with EBV/CMV dual infection often manifest as more severe symptoms who show a much longer febrile period and a higher incidence of complications,including thrombocytopenia,pneumonia and anemia,compared with single EBV infection. Key words: Herpesvirus 4, human;  Cytomegalovirus;  Infection;  Infectious mononucleosis