Application of Thrombelastography for Evaluating the Influence of Platelet Aggregation Function and Activity by Using Tirofiban in the Patients Who Were Undergoing Emergency Intervention with ACS

Objective: To discuss the application of thrombelastography for evaluating the influence of platelet aggregation function and activity by using Tirofiba in the patients who were undergoing emergent intervention with ACS,and to investigate the efficacy and safety of early application of tirofiban on the patients.Methods: 100 cases who were undergoing emergency intervention with ACS were selected and randomly divided into two groups: intervention group(injected tirofiban by 10 μg/kg in 3 minutes,then 0.15 μg/kg/min for 36 hours by,n=50) and control group(without tirofiban,n=50),collectedg blood in 3 times(Immediately divided in groups,after kept tirofiban for 24 hours and after stoping for 24 hours),and recorded inhibition of platelet aggregation rate(IPA)and activity.Results: There was no statistical significance between the two groups(P0.05) when selected.After kept tirofiban for 24 hours,the IPA of intervention group was significantly higher than that of control group[(92.6±8.6)% vs(33.3±9.8)%,P0.01].24 hours after tirofiban stopped,the IPA of the two groups was not statistically significant(P0.05).The activity of platelet was significantly lower than that of the control group[(46.7±10.2)mm vs(59.7±7.8)mm,P0.01].Conclusions: TEG can dynamicaly monitor the function of blood coagulation process and comprehensively assess platelet function and blood coagulation,as well as guiding the plan selection of antiplatelet drugs in ACS patients.The earlier to use tirofiban before emergency intervention in patients with ACS,the better effects we get.It is able to achieve better platelet aggregation inhibition,obtain better immediate angiography results,reduce postoperative ischemic events and improve clinical prognosis.