Antibacterial and antifungal properties of guanylhydrazones

A series of novel guanylhydrazones were designed, synthesized and characterized. All the compounds were screened for their antibacterial and antifungal activity. Compounds 26 and 27 showed excellent antibacterial activities against Staphylococcus aureus ATCC 25923 and Micrococcus luteus ATCC 379 with minimal inhibitory concentrations of 4 µg/mL, and good antifungal activity against Candida parapsilosis ATCC 22019. These results suggested that selected guanylhydrazones could serve as promising leads for the improved antimicrobial development.