Uses and methods to prevent and / or treat caries caused by mutans Streptococci

2007 
Use of a microorganism belonging to the genus Lactobacillus or a mutant or derivative thereof, characterized in that it is capable of specifically binding to a bacterium belonging to the group of mutans Streptococci, wherein the specific binding is (i) resistant to heat treatment, wherein said heat treatment is carried out at a temperature of over 95 ° C for at least 20 minutes; and (ii) resistant to protease treatment, wherein said protease treatment is treatment with a protease selected from the group consisting of pronase E, proteinase K, trypsin and chymotrypsin; and (iii) calcium-dependent; and (iv) formed within a pH range between 4.5 and 8.5; and (v) formed in the presence of saliva, for the preparation of an anticariogenic composition for treating or preventing caries caused by Streptococcus sobrinus joining said Streptococcus sobrinus, wherein said derivative microorganism is an inactive form of said microorganism or an fragment of said microorganism, being inactivated said microorganism thermally or lyophilized, wherein said fragment is a membrane fraction obtained by preparing a membrane and wherein said inactivated form or said fragment retains the capability of specifically binding to a bacterium belonging to group Streptococci mutans.
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