A SIMPLE AND CONVENIENT SYNTHESIS OF 2-PHOSPHONOMETHYL PYRIDINES

Abstract The Michaelis-Becker-Nylen reaction is well suited for the synthesis of 2-phosphonomethyl pyridines. We have improved this four steps method in a one pot reaction using commercial reagents. By this general procedure we have prepared seven new 2-phosphonomethyl pyridines (Ia—g) under mild conditions with higher yields.