Class I HDAC inhibitors inhibit the retention of BRCA1 and 53BP1 at the site of DNA damage.

Takayo Fukuda,Wenwen Wu,Maiko Okada,Ichiro Maeda,Yasuyuki Kojima,Ryosuke Hayami,Yasuo Miyoshi,Koichiro Tsugawa,Tomohiko Ohta

Class I HDAC inhibitors inhibit the retention of BRCA1 and 53BP1 at the site of DNA damage.

2015

Takayo Fukuda
Wenwen Wu
Maiko Okada
Ichiro Maeda
Yasuyuki Kojima
Ryosuke Hayami
Yasuo Miyoshi
Koichiro Tsugawa
Tomohiko Ohta

e13552 Background: BRCA1 and 53BP1 antagonistically regulate homology-directed repair (HDR) and non-homologous end-joining (NHEJ) of DNA double-strand breaks (DSBs). The histone deacetylase inhibit...

Keywords:

DNA damage
Pathology
Cancer research
Medicine
Histone deacetylase
DNA

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