Improving the Efficiency of Chemotherapeutic Drugs by the Action on Neuroepithelial Tumors

The problem of cancer embraces a lot of unresolved issues, among which there dominates the problem of ascertainment of the mechanisms of uncontrolled growth and cellular spill of tumor neoplasm, composed of dividing cancer cells and cancer stem cells (Schatton & Frank MH, 2009; Schatton et al., 2009; Frank NY et al., 2010). It is impossible to answer the question about a complete removal of the tumor tissue and simultaneous minimizing the adverse effects of surgical and other manipulations while removing the tumor without solving this problem. This is a particularly relevant goal for physicians who are engaged in treatment of brain tumors. The destruction of nerve tissue nonaffected by tumor growth has a negative impact on the integrative brain activity and at least on the central control of all bodily functions and homeostasis maintenance. How is it possible to reduce by-effects of major therapeutic technologies in neurooncology (surgical, radiological, chemotherapeutic), having preserved or enhanced their selective tumor damaging action? Since you choose chemotherapy as one of the ways to impact on tumor tissue, it is impossible not to mention the commonly known toxic effect of chemotherapeutic agents on all body tissues. Destroying the tumor cells, cytotoxic agents kill healthy cells and tissues. Thus, local or systemic applying the chemotherapy leads inevitably to the destruction of healthy brain cells in case of the tumor localization within the cranial cavity and the spinal canal. Thus, one of the objectives of this work was to develop methodic of leveling the general toxic effects of chemotherapy while strengthening their local destructive effect on tumor tissue. What ways have been chosen to solve this problem? Tumors of the brain and spinal cord have extremely variety (set) of histological forms which are accounted for their origin from the elements of various tissues and for peculiarity of