Preoperative concomitant chemo-radiotherapy (CT-RT) in non small cell lung cancer patients with superior sulcus tumor (SST): A single institution experience.

7372 Background: SST is an uncommon tumor, usually resected after induction RT. In the recent years some experiences with preoperative chemo-radiotherapy were published. Methods: CT was platinum-based: Carboplatin AUC 5 on days 1 and 22, combined to Mitomycin-C 8 mg/m2, d.1 & 22, and Vinblastine 4mg/m2 dd.1, 8, 22 & 29 (MVC, from 1994 to 1999) or combined to Navelbine 25mg/m2 dd.1, 8, 22 & 29 (NC, from 2000 to 2003). RT was administered 5 dd/week, 30Gy in 10 fractions from dd. 22 to 35 (in the period 1994–96), or 44Gy in 22 fractions, dd.22 to 52 (in the period 1997–2003). Surgery was planned after 2–3 weeks from the end of RT. Results: since 1994 26 pts were treated with induction CT-RT, 1 with induction RT M/F ratio was: 23M/4F, median age 61 years/ range (43–77yrs), median PS was 80 (range 50–80), Histology subtypes were: squamous 11 (41%), adeno 10 (37%), not specified (NSCLC) 6 (21%); stage: 17 had stage IIIa according to TNM-1986 and stage IIb according to TNM-1997, 3 stage IIIa N+, and 7 stage IIIb...