Growth Hormone-Dependent Pathogenesis of Human Hepatic Steatosis in a Novel Mouse Model Bearing a Human Hepatocyte-Repopulated Liver

Chise Tateno,Miho Kataoka,Rie Utoh,Asato Tachibana,Toshiyuki Itamoto,Toshimasa Asahara,Fuyuki Miya,Tatsuhiko Tsunoda,Katsutoshi Yoshizato

Growth Hormone-Dependent Pathogenesis of Human Hepatic Steatosis in a Novel Mouse Model Bearing a Human Hepatocyte-Repopulated Liver

2011

Chise Tateno
Miho Kataoka
Rie Utoh
Asato Tachibana
Toshiyuki Itamoto
Toshimasa Asahara
Fuyuki Miya
Tatsuhiko Tsunoda
Katsutoshi Yoshizato

Human hepatocytes repopulated in mouse liver develop steatosis in a h-GH-dependent manner; the animal model is useful for studying role of h-GH in nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.

Keywords:

Hormone
Steatohepatitis
Steatosis
Nonalcoholic fatty liver disease
Fatty liver
Pathogenesis
Diabetes mellitus
Hepatocyte
Internal medicine
Endocrinology
Biology
growth hormone
Gene expression
human hepatocyte
Animal model

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