Development of a Whole-Body Physiologically Based Pharmacokinetic Model for Colistin and Colistin methanesulfonate (CMS) in Rat

Salim Bouchene,Sandrine Marchand,William Couet,Lena E. Friberg,Patrice Gobin,Isabelle Lamarche,Nicolas Grégoire,Sven Björkman,Mats O Karlsson

Development of a Whole-Body Physiologically Based Pharmacokinetic Model for Colistin and Colistin methanesulfonate (CMS) in Rat

2016

Salim Bouchene
Sandrine Marchand
William Couet
Lena E. Friberg
Patrice Gobin
Isabelle Lamarche
Nicolas Grégoire
Sven Björkman
Mats O Karlsson

Colistin is a polymyxin antibiotic which is used to treat patients infected with multidrug resistant Gram negative bacteria (MDR-GNB). The objective of this work was to develop a whole-body physiol ...

Keywords:

Pharmaceutical sciences
Colistin
Pharmacology
Multidrug-resistant gram-negative bacteria
Microbiology
Pharmacokinetics
Medicine
Polymyxin Antibiotic
whole body

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