Comparison of Survival Analysis between Surgical and Non-surgical Treatments in Duchenne Muscular Dystrophy Scoliosis.
2020
Abstract Background Context There are still controversies about the effects of spinal surgeries for Duchenne muscular dystrophy (DMD) scoliosis on functional outcome, respiratory function, and the survival rate. Purpose The purpose of this retrospective investigation was to compare the clinical course over time between the patients who were treated surgically and those who were treated non-surgically. Through this comparison, we tried to determine how surgical treatment could affect the functional status, pulmonary function, and survival rate in patients with DMD scoliosis. Study design/Setting Single-center retrospective cohort study. Patient sample We reviewed the clinical data of 199 male patients with DMD scoliosis who were followed up at our center for an average of 6.4 years between 2003 and 2017. Outcome measures The basic radiologic parameters evaluated include the Cobb angle and pelvic obliquity on a whole spine X-ray. Further, the Swinyard scale for functional status, forced vital capacity (FVC) for respiratory function, and mortality were compared between the surgical group and non-surgical group. Methods The radiologic parameters and Swinyard scale stage were compared between the surgical group and non-surgical group at baseline and 2, 5, and 10 years. For the FVC, serial changes every year were investigated in both groups. Mortality was surveyed between the surgical group and non-surgical group. Results Of the 199 patients, 99 patients underwent the instrumented spinal fusion surgery and 100 patients in the non-surgical group opted for conservative management. Radiologic results of the two groups were not different at baseline, but during the follow-up periods, the surgical group demonstrated better Cobb angles and pelvic obliquities. The surgical group showed a better functional status than did the non-surgical group (6.7±0.9 versus [vs.] 7.2±0.7, p Conclusions Spinal surgery for DMD scoliosis improved the FVC for approximately 2 years postoperatively compared to non-surgical treatment. The surgical group had a better functional status and FVC at baseline than the non-surgical group. The positive effect of surgical treatment on the FVC is owing to scoliosis correction, which delayed the decrease of FVC and consequently extended the survival rate of the patients with DMD scoliosis.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
31
References
0
Citations
NaN
KQI