Prediction of major complications in patients with solid tumors and apparently stable febrile neutropenia: Validation of the CISNE risk score.

9620 Background: In order to improve the risk stratification of patients with febrile neutropenia (FN), we previously developed a prognostic score predicting major complications in patients with solid tumors and apparently stable episodes (Br J Cancer. 2011;105[5]:612-7). Methods: On the basis of our previous multivariate analysis, 6 predictors were associated to serious complications [ECOG PS≥2 (2points), chronic obstructive pulmonary disease (1point), cardiovascular disease (1point), mucositis NCI grade≥2 (1point), monocytes <200 (1point) and stress-induced hyperglycemia (2points)]. We have integrated these factors into a score ranging from 0 to 8, which allows the classification of patients into 3 prognostic classes: low (0points), medium (1-2points) and high risk (≥ 3points). We present here a validation of this score (CISNE) and a comparison with MASCC and Talcott models. Results: From Oct/12 to Dec/13, we prospectively recruited 780 patients with apparently stable FN from 21 hospitals. The rate of i...