Study On Protective Efficacy of HBIG Combining With HBsAg Vaccine in Blocking Mother-Infant Transmission of Hepatitis B Virus

Objective This study was to investigate the preventive efficacy of HBIG combining with HBsAg Vaccine in Bloking Mother-Infant Transmission of Hepatitis B Virus; Methods 225 infants, whose mother with hepatitis B surface antigen (HBsAg) carrier, were divided into 2 group, HBvac 30ug was given at 0,1,6 month in control group, while at pregnancy and birth combining with HBIG 200IU in caring group, serum HBsAg was followed up for one year. Results chronicity of HBsAg in children with HBsAg positive at birth decreased And the incidence of chronic HBSAg infection deceased from 12.7% to 4.06%, compared to caring group in I year(P0.05). Conclusions combing therapy of HBIG and HBvac may interrupt maternal-infantive transmission and decrease the chronic HBSAg infection. It should be pay close attention to whole society.