Divergent effects of conditioned pain modulation on subjective pain and nociceptive-related brain activity

Background and objectives Pain is a complex experience involving both nociceptive and affective–cognitive mechanisms. The present study evaluated whether modulation of pain perception, employing a conditioned pain modulation (CPM) paradigm, is paralleled by changes in contact heat-evoked potentials (CHEPs), a brain response to nociceptive stimuli.