Phenylephrine and endothelin-1 upregulate connective tissue growth factor in neonatal rat cardiac myocytes

Abstract Cardiac hypertrophy is associated with hypertrophic growth of cardiac myocytes and increased fibrosis. Much is known of the stimuli which promote myocyte hypertrophy and the changes associated with the response, but the links between the two are largely unknown. Using subtractive hybridization, we identified three genes which are acutely (