Manganese-Catalyzed Hydroboration of Terminal Olefins and Metal-Dependent Selectivity in Internal Olefin Isomerization–Hydroboration

In the past decade, the use of earth-abundant metals in homogeneous catalysis has flourished. In particular, metals such as cobalt and iron have been used extensively in reductive transformations including hydrogenation, hydroboration, and hydrosilylation. Manganese, on the other hand, has been considerably less explored in these reductive transformations. Here, we report a well-defined manganese complex, [Mn(iPrBDI)(OTf)2] (2a; BDI = bipyridinediimine), that is an active precatalyst in the hydroboration of a variety of electronically differentiated alkenes (>20 examples). The hydroboration is specifically selective for terminal alkenes and occurs with exclusive anti-Markovnikov selectivity. In contrast, when using the analogous cobalt complex [Co(iPrBDI)(OTf)2] (3a), internal alkenes are hydroborated efficiently, where a sequence of isomerization steps ultimately leads to their hydroboration. The contrasting terminal versus internal alkene selectivity for manganese and cobalt was investigated computationally and is further discussed in the herein-reported study.