Topic: Hemophagocytic lymphohistiocytosis secondary to sars covid 19: A case report

Aims & Objectives: INTRODUCTION: Hemophagocyticlym phohistiocytosis (HLH) is a severe, life-threatening inflammatory syndrome associated with intensecytokinerelease (also known as a ''cytokinestorm'') HLH can occur as familial (primary) or acquired (secondary) disorder that may be difficult to distinguish from one another Secondary form is triggered by various causes including viral infections and is characterized by aggressive course leading to multiorganfailure We plan to discuss the clinical and laboratory features of hemophagocyticlympho histiocytosiss econdary to covid19 Patients/Materials & Methods: CASEREPORT: A 64 yr old female came with complain so fever, breath lessness and cough since 5 days She was a known case hypertension and diabetesmellitus She wastested SARSCoV-2-POSITIVE by conventional RT-PCR test On further evaluation she showed feature s of bilateral pneumonia Results: Hematological parameters revealed Pancytopenia Serum ferritin was raised (603 microgm/L) along with ESR(78 mm/hr) Bone marrow aspirate and biopsy showed features of hemophagocytosis Patient was treated with dexamethasone, remdesivir, oxygen in intensive care with good clinical response Discussion & Conclusion: CONCLUSION: Mortality of HLH is very high without early diagnosis and appropriate treatment Hence, a screening of all COVID19 positive patients is highly recommended to analyze hyper inflammation using laboratory tests and Hs core which can improve the outcomes A multidisciplinary team of experts is required to provide patients with appropriate treatment