Microwave Assisted Synthesis of 3 (2, 7- Dichloro-6-Flouroquinolin -3yl) -1-(Substituted Aryl) Prop-2-En-1-Ones Derivatives for Anti-Microbial Activities

In an attempt to standardize a method of microwave assisted synthesis for some fluoro chloro quinoline derivatives, we have synthesized N-(3-chloro-4-fluorophenyl) acetamide. From this compound a formylated quinoline ring was prepared i.e. 2,7- dichloro6-fluoro-quinoline-3-carbaldehyde which was then subjected to reaction with Vilsmeier–Haack reagent (POCl3, DMF) under microwave irradiations at different energy levels 3(2,7-dichloro-6-fluoroquinolin-3yl)-1-(substituted aryl)prop-2-en-1-one derivatives (a) were prepared by fusing substituted aromatic ketones. Structural identification of these compounds were established by IR, 1 H NMR, and Mass spectra. All the synthesized compounds were evaluated for antimicrobial activity against of Staphylococcus aureus (Gram +ve) and Pseudomonas aeruginosa (Gram -ve) bacterial strains by agar diffusion method. Among all the test compounds RS01 and RS-07 has shown significant activity as compared to standard ampicillin, the other test compounds has shown minimal antimicrobial activity.