Impact of moderate to severe renal impairment on long-term clinical outcomes in patients with atrial fibrillation

Abstract Background The deleterious effect of renal impairment in non-valvular atrial fibrillation (AF) patients has recently been reported. We investigated the impact of moderate to severe renal impairment on long-term clinical outcomes in AF patients. Methods A total of 2126 AF patients were enrolled and divided into two groups according to ≥ or Results Compared to the ≥60 mL/min eGFR group, 2 , CHA 2 DS 2 -VAS c , and HAS-BLED scores. During the follow-up period (median 6.23 years), all-cause death, bleeding, admission for HF, and progression to persistent or permanent AF were significantly increased in the p  = 0.04] and bleeding (HR: 1.28; 95% CI: 1.04–1.57, p  = 0.02). IS was only significantly increased in the Conclusion Moderate to severe renal impairment is a poor prognostic factor of long-term clinical outcomes in AF patients.