Effect of CPDX-PR on Pediatric Infections.

We investigated the clinical and bacteriological effects of Cefpodoxime proxetil (CPDX-PR) in pediatric infections in 118 boys and 111 girls aged one month to 14 years and 7 months. The diagnosis was acute otitis media in 89, acute tonsillitis in 81, acute pharyngolaryngitis in 34, paranasal sinusitis in 22, and other infections in 3. The daily dose of CPDX-PR was usually 9 mg/kg, but some adjustments were made depending on the effect. In 165 patients the causative organisms were cultured: H. influenzae was the most common, followed by S. aureus and S. pneumoniae. Gram-positive bacteria were detected in 54.2%, Gram-negative bacteria in 45.3%, and fungi in 0.5%. The incidence of Gramnegative infection is higher in children than in adults. The efficacy rate was 91.3%. Side effects were noted in 4 patients but they were mild. Rapid hematological effects on WBC counts, ESR, and differential counts were observed with the administration of CPDX-PR.