Psychosocial impact of cancer-related symptoms among patients with lung cancer

6621 Background: Patients with lung cancer may experience adverse physical symptoms due to cancer, cancer treatment, or comorbid medical conditions. These cancer-related symptoms (CRS) may be associated with functional impairment (FI), and may affect psychosocial functioning. Methods: We conducted a retrospective analysis of self reported symptom burden with the 38-item Patient Care Monitor survey (PCM), collected as part of routine clinical care in 1,384 lung cancer patients identified by ICD-9 codes at 8 community oncology practices in the US. Structural equation models were built among 672 randomly selected patients to examine the relationships of CRS and of FI on psychosocial symptoms and to determine whether FI mediates the effect of CRS. Results: Patients were 47.7% female, with mean age of 66 years (23–91), 65% Caucasian, 16% African American, 19% other/unknown race. Stage of disease was 19% stage IV, 22% stage I-III, and 59% unspecified. Histological type was 36% adenocarcinoma, 18% squamous cell,...