Tetrahydropyridine derivatives with inhibitory activity on the production of proinflammatory cytokines: Part 1

Abstract We investigated proinflammatory cytokine TNFα production inhibitors in order to develop novel anti-inflammatory agents. According to the results, we found that 17 , a pyrrole derivative possessing a tetrahydropyridine group at the β-position, showed potent inhibitory activity in vitro (inhibition of lipopolysaccharide (LPS) induced TNFα production in human whole blood, IC 50  = 1.86 μM) and in vivo (inhibition of LPS induced TNFα production in mice, ID 50  = 5.98 mg/kg).