Method for producing fluorine-containing cyclopropane carboxylic acid compound

2016 
The present invention provides an industrially practicable method for producing a fluorine-containing cyclopropane carboxylic acid compound that is useful as an intermediate for pharmaceuticals and agrochemicals. A fluorine-containing cyclopropane monoester is obtained by: producing a fluorine-containing cyclic sulfuric acid ester with use of a fluorine-containing diol compound and sulfuryl fluoride (a cyclic sulfuric acid esterification step); obtaining a fluorine-containing cyclopropane diester by reacting the thus-obtained fluorine-containing cyclic sulfuric acid ester and a malonic acid diester with each other (a cyclopropanation step); and hydrolyzing the thus-obtained fluorine-containing cyclopropane diester (a hydrolysis step). In addition, a fluorine-containing cyclopropane carboxylic acid compound such as a fluorine-containing cyclopropane monoester or a salt thereof having high chemical purity and high optical purity is able to be produced by forming a salt of an amine and a fluorine-containing cyclopropane monoester by mixing the thus-obtained fluorine-containing cyclopropane monoester and an amine and performing recrystallization purification (a recrystallization step).
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