Qui régit la spécificité de transport des oligopeptides chez Lactococcus lactis

Who determines the diversity of oligopeptide transport specificity in Lactococcus lactis? In this review our knowledge of oligopeptide transport by Opp in Lactococcus lactis is discussed. The specific oligopeptide transport system Opp is essential for growth of lactic acid bacteria in milk. This system belongs to the superfamily of ABC transporters containing a binding protein, generally described as the determinant of the specificity. The substrate specificity of this system, studied on one strain of lactococci, L. lactis MG1363, appears to be very different from that of other bacteria, especially Salmonella typhimurium. Relatively broad, this specificity is not fully representative of that of L. lactis species. In fact, each strain displays specific preferences for peptide transport. Despite binding protein OppA sequence varies to one strain to another, its variability cannot explain the observed diversity of substrate specificity. In L. lactis, OppA is essential for peptides transport but does not entirely determine the substrate specificity and its diversity among the species. Lactococcus lactis / oligopeptide transport / specificity / diversity