AB0477 THE EFFECT OF CLOSTRIDIUM BUTYRICUM ON INTESTINAL FLORA OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

Objectives: To investigate the effect of Clostridium butyricum on intestinal flora in patients with systemic lupus erythematosus. Methods: Forty-four patients with systemic lupus erythematosus who were randomly selected from our hospital were given the oral administration of Clostridium butyricum live capsule 840mg twice a day. The concentration of methane and hydrogen at each time point before and after treatment for 44 patients was detected and compared by hydrogen and methane in lactulose breath test (LBT). Results: After 28 days of treatment with Clostridium butyricum capsules, there was no significantly statistical difference in exhaled hydrogen concentration or methane concentration between 0 min, 30 min, 60 min and 90 min before and after treatment. See Table 1. Conclusion: Numerous studies have shown that taking probiotics can promote the growth of normal flora and reduce the reproduction of other abnormal flora, which has a certain impact on the structure and quantity of There was no significantly statistical difference in exhaled hydrogen concentration or methane concentration at various points in time between the 44 patients before and after treatment, suggesting that there was no significant change in the structure and quantity of intestinal flora. intestinal flora, which may be resulted from our low dose Clostridium butyricum live capsules or short treatment time, or need to be combined with other probiotics. These hypothesis above need us to further explore, in general, using microbes as a therapeutic target spot to regulate the illness of SLE by interfering with intestinal flora through diet, probiotics or fecal transplantation provides a promising prospect for clinical treatment of SLE. Using Wilcoxon test, P Disclosure of Interests: None declared