The Effectiveness of Extract Snack Head Fish and Virgin Coconut Oil (VCO) on Sputum Conversion and Levels of Interferon-ɣ in Patients with Pulmonary TB Multi Drug Resistant (MDR) in Labuang Baji Hospital Makassar

Background: Treatment of pulmonary MDR TB disease is relatively very expensive and takes a long time to heal, This study aims to determine the effect of treatment DOTS-Plus capsules supplemented catfish albumin protein coupled VCO can affect the conversion of sputum smear and levels of interferon-ɣ in pulmonary MDR TB patients who received treatment DOTS-Plus in Labuang Baji Hospital, Makassar. This study is a quantitative study with randomized controlled quasi-experimental approach with a sample size of 30 people (15 experimental, 15 control). Data analysis was done using the Independent Sample T Test with a confidence level of 95%. All the data were Analyzed by SPSS software, version 21.0 (SPSS, Inc., Chicago, IL). Results: All the groups in which I no conversion. The intervention began in the second conversion of 80% and all had more conversions in III. Control in II started there is a conversion of 53.3% and until VI there are still 3.3% which is not convertible. The average levels of interferon gamma first month (intervention: 153.26 ± 27.19; control 150.60 ± 29.55), three month (intervention: 179.00 ± 48.89; control: 140.46 ± 20, 03) . Sixth months (intervention: 152.00 ± 70.74; Controls: 150.93 ± 18.65). The results showed pulmonary MDR TB patients receive treatment DOTS Plus capsules albumin supplemented catfish coupled VCO accelerate the conversion of sputum (p = 0.038) and improve the levels of interferon-ɣ (p = 0.011).  In conclusion, MDR pulmonary tuberculosis patients received treatment DOTS Plus capsules albumin supplemented catfish plus VCO will accelerate the conversion of sputum, improve levels of interferon-ɣ. By him that, to be considered for albumin supplementation capsules catfish coupled VCO in the treatment of pulmonary tuberculosis.