The impact of myeloperoxidase in the rupturing of cerebral aneurysms.

OBJECTIVES In this study, we aimed to examine the effect of myeloperoxidase on aneurysm rupture in patients with cerebral aneurysms with and without rupture. PATIENTS AND METHODS The study included 53 patients with subarachnoid hemorrhage (SAH) operated on due to cerebral aneurysm in our clinic and 49 patients without SAH. After the operation, the domes taken from the aneurysms were embedded in paraffin blocks and scored after hematoxylin & eosin and immunohistochemical staining was carried out. RESULTS The myeloperoxidase score was 1 in 29.4% of the patients, 2 in 40.2%, 3 in 12.7%, and 4 in 17.6%. Multiple aneurysms were detected in 24.5% of the patients. The median myeloperoxidase score was higher in patients with bleeding aneurysms than those that did not bleed (3 vs. 1; p < 0.001). In addition, the ratio of patients with a myeloperoxidase score of 2 or above was higher among patients with bleeding aneurysms. CONCLUSION In our study, finding myeloperoxidase scores higher in cases of ruptured aneurysms compared to unruptured aneurysms reveals the relationship of myeloperoxidase with ruptured cerebral aneurysms.