[Association study between HLA-DRB genes and asthmatic children].

Abstract To investigate the distribution of HLA-DRB alleles among the asthmatic children and find the alleles with a correlation with susceptibility or resistance to childhood asthma. The sequence-specific polymerase chain reaction (SSP-PCR) was used to analyze the HLA-DRB genotype in 117 asthmatic children and 120 healthy children in Beijing. Then the frequency of each type, odds ratio (OR) and the 95% confidence interval (CI) of OR were calculated. The frequency of DR2 (15) in the asthmatic children was 12.0% (28/234) vs 5.4% (13/240) in the healthy children. The frequency was significantly higher than that of nonasthmatic children (OR = 2.590, 95% CI = 1.266-5.298, Chi(2) = 6.431, P