Abstract 14694: Combined Assessment of Urinary Liver-Type Fatty-Acid Binding Protein and Albumin Improves Prediction of Acute Kidney Injury in Patients Hospitalized to Coronary Care Units

Background: Urinary concentration of liver-type fatty-acid binding protein (L-FABP) reflects tubulointerstitial damage, and urinary albumin concentration (UAC) reflects glomerular damage. We prospectively investigated the predictive value of urinary L-FABP, both independently and in combination with UAC for acute kidney injury (AKI) which develops after admission to coronary care units (CCUs). Methods: We studied 1139 patients (mean age of 69 yrs) who admitted to CCUs. Baseline urinary L-FABP and UAC were measured on admission. Among these patients, heart failure was present in 43%, and acute coronary syndrome in 45%. AKI was diagnosed and classified according to the KDIGO criteria. Results: Urinary L-FABP levels moderately correlated with UAC (r = 0.42, p < 0.0001). AKI occurred in 223 (19.6%) patients. Comparably, patients with AKI were older (73 vs. 71 yrs, p = 0.01), had a higher prevalence of heart failure (51 vs. 41%, p = 0.007), higher levels of B-type natriuretic peptide (377 vs. 206 pg/ml, p < 0....