Skin Wound Healing Assisted by Angiogenic Targeted Tissue Engineering: a Comprehensive Review of Bioengineered Approaches.

Skin injuries and in particular, chronic wounds, are one of the major prevalent medical problems, worldwide. Due to the pivotal role of angiogenesis in tissue regeneration, impaired angiogenesis can cause several complications during the wound healing process and skin regeneration. Therefore, induction or promotion of angiogenesis can be considered as a promising approach to accelerate wound healing. This article presents a comprehensive overview of current and emerging angiogenesis induction methods applied in several studies for skin regeneration, which are classified into the cell, growth factor, scaffold, and biological/chemical compound-based strategies. In addition, the advantages and disadvantages of theseangiogenicstrategiesalong with related research examples are discussed in order to demonstratetheir potential in the treatment ofwounds.