A Novel Chinese Medicine, Xinfeng Capsule, Modulates Proinflammatory Cytokines via Regulating the Toll-Like Receptor 4 (TLR4)/Mitogen-Activated Protein Kinase (MAPK)/Nuclear Kappa B (NF-κB) Signaling Pathway in an Adjuvant Arthritis Rat Model
2019
Background
Rheumatoid arthritis (RA) is a chronic autoimmune disease targeting joints. This research aimed to explore the effects of Xinfeng capsules (XFC) on cardiac injury in adjuvant arthritis (AA) model rats and assessed the associated mechanism.
Keywords:
- NF-κB
- Traditional Chinese medicine
- Signal transduction
- Internal medicine
- Mitogen-activated protein kinase
- TLR4
- Endocrinology
- MAPK/ERK pathway
- Proinflammatory cytokine
- Cancer research
- Medicine
- Toll-like receptor
- p38 mitogen-activated protein kinases
- Triptolide
- Interleukin 6
- Tumor necrosis factor alpha
- Interleukin 17
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