Nano-hydroxyapatite/polyamide66 composite scaffold conducting osteogenesis to repair mandible defect

In this study, nano-hydroxyapatite/polyamide66 composite scaffold was prepared by combining thermally induced phase separation and particulate leaching. The morphological structure and compositional phases of the scaffold were analyzed, while the in vitro and in vivo biological behaviors were assessed by comparing with the control of the commercial porous polyethylene (MEDPOR®). Results indicate that nano-hydroxyapatite/polyamide66 scaffold showed excellent biocompatibility and the ability to accelerate bone marrow mesenchymal stem cells differentiation in vitro and bone marrow mesenchymal stem cells/nano-hydroxyapatite/polyamide66–engineered constructs exhibited much better in vivo biocompatibility and osteoconductivity with the surrounding host bone than bone marrow mesenchymal stem cells/MEDPOR constructs. The porous nano-hydroxyapatite/polyamide66 scaffold demonstrates a potential to be applied in the orthopedic or maxillofacial surgery.