Analysis on seven virus detection results of 15 636 children with respiratory tract infection in Wuhan Children's Hospital, 2019

Objective  To analyze the epidemiologic characteristics of common respiratory virus infection in hospitalized children in Wuhan Children's Hospital from January to December 2019, and provide evidence for clinical diagnosis and treatment. Methods  Nasopharyngeal swabs were collected from the hospitalized children with respiratory infection from January to December 2019. Seven respiratory virus antigens of parainfluenza virus type 1, type 2, type 3 (PIV1, 2, 3), influenza virus A, influenza virus B, adenovirus (ADV) and respiratory syncytial virus (RSV) were detected by direct immunofluorescence assay, and the general information of the children were collected and analyzed. Results  A total of 15 636 nasopharyngeal swabs were collected from the hospitalized children with respiratory infection in Wuhan Children's Hospital in 2019, and the total positive rate was 27.26%. The positive rates of RSV, ADV, PIV 3, influenza virus B, influenza virus A, PIV 1 and PIV 2 were 8.58% (1 341/15 636), 8.06% (1 261/15 636), 6.47% (1 012/15 636), 1.27% (198/15 636), 1.20% (188/15 636), 1.15% (181/15 636), and 0.83% (129/15 636), respectively. The positive rate of RSV was highest. The overall positive rate of seven viruses in boys was higher than that in girls, and the difference was significant (χ2= 21.031, P 0.05). In all age groups, the detection rates in age groups 6 months-1 year and Conclusion  The overall positive rate of the seven viruses in children with respiratory tract infection in 2019 varied with gender, age and season in Wuhan, to which physicians should paid attention in clinical diagnosis.