Анализ влияния сверхвысокомолекулярного полиэтилена высокой плотности на некоторые биохимические показатели крови в эксперименте

Objectives. To evaluate the influence of the material from the modified ultra-high molecular weight polyethylene of high density (UHMWPE) at its implantation in the ear bulla of a rabbit on some biochemical blood parameters in comparison with titanium, which is widely applied in otosurgery. Methods. 35 rabbits were used to carry out the experiment; they were divided into 3 groups. The 1st as well as the 2nd group included 15 animals which were excluded from the experiment 15, 60 and 90 days afterwards (5 animals in each term); the 3rd group was a control one (5 rabbits). In the 1st group implants from the modified ultra-high molecular weight polyethylene were used; in the 2nd group from titanium; the 3rd group wasn't operated on at all. Results. While comparing two experimental groups of animals with the control group reliable differences in the blood content of bilirubin, AST, glucose, creatinine, total protein in different terms after operation were not revealed. Conclusions. UHMWPE can be regarded as a material suitable for further investigations aimed to work out the original domestic construction of prosthesis of the ossicular chain.