Atrial natriuretic peptide (ANP), aldosterone, angiotensin II and renin in the low T3 syndrome' in organ donors

The present prospective study was conducted in order to investigate the effect of an acute decrease in serum T3 levels on ANP, aldosterone, angiotensin II, renin and ADH. All patients showed a pathologic TRH stimulation test prior to organ harvesting. Our patients developed secondary T3 hypothyroidism of different severity dependent on intensive care unit (ICU) stay. T3 values in group 1 (ICU stay > 77 h) were smaller than 70 ng/dl, those of group 2 (ICU stay